A road map for the treatment of pediatric diffuse midline glioma

- Koschmann, Carl, Al-Holou, Wajd N., Clausen, Madison, Dang, Derek, Doherty, Robert, Duchatel, Ryan, Dun, Matthew, Filbin, Mariella, Franson, Andrea, Galban, Stefanie, Garcia Moure, Marc, Garton, Hugh, Alonso, Marta M., Gowda, Pruthvi, Marques, JG, Hawkins, C, Heath, A, Hulleman, E, Ji, S, Jones, C, Kilburn, L, Kline, C, Koldobskiy, MA, Anastas, Jamie, Lim, D, Lowenstein, PR, Lu, QR, Lum, J, Mack, S, Magge, S, Marini, B, Martin, D, Marupudi, N, Messinger, D, Bandopadhayay, Pratiti, Mody, R, Morgan, M, Mota, M, Muraszko, K, Mueller, S, Natarajan, SK, Nazarian, J, Niculcea, M, Nuechterlein, N, Okada, H, Barron, Tara, Opipari, V, Pai, MP, Pal, S, Peterson, E, Phoenix, T, Prensner, JR, Pun, M, Raju, GP, Reitman, ZJ, Resnick, A, Becher, Oren, Rogawski, D, Saratsis, A, Sbergio, SG, Souweidane, M, Stafford, JM, Tzaridis, T, Venkataraman, S, Vittorio, O, Wadden, J, Wahl, D, Cartaxo, Rodrigo, Wechsler-Reya, RJ, Yadav, VN, Zhang, X, Zhang, Q, Venneti, S, Castro, Maria G., Chung, Chan

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

- Duchatel, Ryan J., Jackson, Evangeline R., Kearney, Padraic S., Jamaluddin, M. Fairuz B., Douglas, Alicia M., Beitaki, Tyrone, McEwen, Holly P., Persson, Mika L., Hocke, Emily A., Jain, Vaibhav, Aksu, Michael, Manning, Elizabeth E., Parackal, Sarah G., Murray, Heather C., Verrills, Nicole M., Hua, Susan, Cairns, Murray J., Alvaro, Frank, Dayas, Christopher V., Dun, Matthew D., Hua, S, de Bock, CE, Colino-Sanguino, Y, Kiltschewskij, Dylan, Valdes-Mora, F, Tsoli, M, Ziegler, DS, Cairns, MJ, Raabe, EH, Vitanza, NA, Hulleman, E, Phoenix, TN, Koschmann, C, Alvaro, F, Findlay, Izac J., Dayas, CV, Tinkle, CL, Wheeler, H, Whittle, JR, Eisenstat, DD, Firestein, R, Mueller, S, Valvi, S, Hansford, JR, Ashley, DM, Mannan, Abdul, Gregory, SG, Kilburn, LB, Nazarian, J, Cain, JE, Dun, MD, Staudt, Dilana E., Thomas, Bryce C., Germon, Zacary P., Laternser, Sandra

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

- Venneti, Sriram, Kawakibi, Abed Rahman, Ramage, Samuel, Chi, Andrew, Wen, Patrick Y., Arrillaga-Romany, Isabel, Batchelor, Tracy T., Butowski, Nicholas A., Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca A., de Groot, John, Ji, Sunjong, Mehta, M, Hall, MD, Daghistani, D, Cloughesy, TF, Ellingson, BM, Beccaria, K, Varlet, P, Kim, MM, Umemura, Y, Garton, H, Waszak, Sebastian M., Franson, A, Schwartz, J, Jain, R, Kachman, M, Baum, H, Burant, CF, Mottl, SL, Cartaxo, RT, John, V, Messinger, D, Sweha, StefanR, Qin, T, Peterson, E, Sajjakulnukit, P, Ravi, K, Waugh, A, Walling, D, Ding, Y, Xia, Z, Schwendeman, A, Hawes, D, Mota, Mateus, Yang, F, Judkins, AR, Wahl, D, Lyssiotis, CA, de la Nava, D, Alonso, MM, Eze, A, Spitzer, J, Schmidt, SV, Duchatel, Ryan J., Pun, Matthew, Dun, Matthew D., Cain, JE, Jiang, L, Stopka, SA, Baquer, G, Regan, MS, Filbin, MG, Agar, NYR, Zhao, L, Kumar-Sinha, C, Deogharkar, Akash, Mody, R, Chinnaiyan, A, Kurokawa, R, Pratt, D, Yadav, VN, Grill, J, Kline, C, Mueller, S, Resnick, A, Nazarian, J, Chung, Chan, Allen, JE, Odia, Y, Gardner, SL, Koschmann, C, Tarapore, Rohinton S.

ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma

- Jackson, Evangeline R., Duchatel, Ryan J., Le Grand, Marion, Kearney, Padraic S., Douglas, Alicia M., Findlay, Izac J., Germon, Zacary P., McEwen, Holly P., Beitaki, Tyrone S., Patabendige, Adjanie, Skerrett-Byrne, David A., Nixon, Brett, Staudt, Dilana E., Smith, Nathan D., Day, B, Manoharan, N, Nagabushan, S, Hansford, JR, Govender, D, McCowage, GB, Firestein, R, Howlett, M, Endersby, R, Persson, Mika L., Gottardo, NG, Alvaro, F, Waszak, SM, Larsen, MR, Colino-Sanguino, Y, Valdés-Mora, F, Rakotomalala, A, Meignan, S, Pasquier, E, Andre, N, Mannan, Abdul, Hulleman, E, Eisenstat, DD, Vitanza, NA, Nazarian, J, Koschmann, C, Mueller, S, Cain, JE, Dun, MD, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, W. Samantha N.

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

- Przystal, Justyna M., Cosentino, Chiara Cianciolo, Biery, Matt C., Myers, Carrie, Olson, James M., Panditharatna, Eshini, Kritzer, Bettina, Mourabit, Sulayaman, Vitanza, Nicholas A., Filbin, Mariella G., de Iuliis, Geoffry N., Dun, Matthew D., Yadavilli, Sridevi, Koschmann, C, Cain, JE, Grotzer, MA, Waszak, SM, Mueller, S, Nazarian, J, Zhang, Jie, Laternser, Sandra, Bonner, Erin R., Prasad, Rachna, Dawood, Adam A., Lobeto, Nina, Chong, Wai Chin

Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

- Duchatel, Ryan J., Mannan, Abdul, Kearney, Padraic S., Smith, Nathan D., Hindley, Kate E., Cain, Jason E., André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N., Nazarian, Javad, Irish, Kathleen, Woldu, Ameha S., Alvaro, Frank, Eisenstat, DD, Beck, A, Vitanza, NA, Mueller, S, Morris, JC, Dun, Matthew D., Hawtrey, Tom, Hindley, Phoebe A., Douglas, Alicia M., Jackson, Evangeline R., Findlay, Izac J., Germon, Zacary P., Staudt, Dilana